For anyone that's been hiding under a rock for the past year or so, Cedega is Transgaming's latest WINE derivative. It takes most of the WINE codebase and rolls it in with licensed DRM code and some hacked libraries specially engineered for cross platform game play. Add in Point2Play for graphical install and program management and it shouldn't be much of a hastle to run Windows native games through Linux.
Check out PCBurn's Cedega review